Mycotic Diseases
Excessively high humidity, low environmental temperature, concurrent disease, malnutrition, and stress from poor husbandry may be factors in the development of mycotic diseases in reptiles. Little is known about the pathogenesis of systemic mycoses, which can develop over a long period, but maintaining good sanitation and husbandry reduces the frequency of infection.
Aspergillus,
Metarhizium,
Mucor,
Paecilomyces, and
Penicillium spp are a few of the organisms that have been isolated from reptiles with systemic mycoses. Reports of successful treatment of systemic mycoses in reptiles are few. Suggested treatments for deep fungal respiratory infections include amphotericin B (5 mg/kg body wt, nebulized in 150 mL of saline for 1 hr, bid), and thiabendazole (50 mg/kg) and ketoconazole (35 mg/kg) in combination, administered PO, sid. For superficial or localized mycotic infections, surgical removal of the granuloma with local wound treatment is advised.
Basidiobolus spp, pathogenic for mammals, are found in feces of normal reptiles.
Dermatophytosis has been described in all orders of reptiles.
Geotrichum,
Fusarium, and
Trichosporon are the genera most frequently isolated. In most cases, cutaneous injury precedes a secondary fungal infection. Chelonians with fungal infections of the shell can be treated by local debridement and topical application of Lugol’s solution or povidone-iodine. Griseofulvin, at 20-40 mg/kg, PO, every 72 hr for 5 treatments, has been recommended for mycotic skin infections. Topical 1% tolnaftate cream has also been effective. Exposure to ultraviolet light also may be beneficial.
Ulceration of GI tissues has been associated with infections by
Mucor and
Fusarium spp. Chronic visceral granulomatous disease of liver, kidneys, and spleen has been caused by
Metarhizium and
Paecilomyces spp. Few signs other than weight loss are seen before death. Animals may continue to feed until a few days before death.
The most frequent sites of mycotic infection are the skin and respiratory tract.
Metarhizium,
Mucor, and
Paecilomyces spp are frequent isolates.
Aspergillus spp has been isolated from pulmonary lesions in the chuckwalla (
Sauromalus obesus). Most infections involve granuloma or plaque formation with resultant signs of respiratory distress before death.
Candidiasis in large snakes has been treated with nystatin (100,000 U, PO, for 10 days).
[Source:
The Merck Veterinary Manual]