Small snakes bites probably won't even break the skin, and while a larger snake can cause bleeding and pain it's not a life or death thing. Good hygiene and first aid should be all you need to be safe if you get bit.
While there are some jerk snakes, and aggressive breeds, many snake bites are "user error". Things like not washing hands after handling food or other pets, not using tongs to feed enthusiastic individuals, startling the snake, not paying attention to its body language etc. I've not been bitten (yet) by either of my snakes but they are both usually calm. So far I've come close when my corn snake was confused about which hand the food was in, but that was my fault and I could see it coming.
It won't be as disruptive to the snakes' life to be handled at night though if they are a nocturnal species, or one with a especially calm temperament. It may just want to sleep in your sleeve anyway. Snakes don't really "like" handling so much as learn to tolerate it. That said, Jen is totally right, like any other animal snakes can get used to not being handled and become grumpy or moody. Even if you raise it from a baby lack of interaction can lead to a willful pet.
I forgot to mention last time - leopard and crested geckos can live around 20 years, snakes 20+.